Photodynamic therapy in the root canal treatment of primary teeth: A systematic review of clinical trials.

BACKGROUND: Dental caries is the most common oral disease worldwide, and it is estimated to affect 2.3 billion people, with at least 530 million of them being schoolchildren with decayed primary teeth. This condition can rapidly evolve into irreversible pulp inflammation and pulp necrosis and thus requiring endodontic intervention. Photodynamic therapy (PDT) is a supplementary method to conventional pulpectomy and is used to improve the protocol used for disinfection. AIM: The main objective of this study was to evaluate through a systematic review the efficacy of supplementary PDT on the pulpectomy of primary teeth. This review was registered a priori on the PROSPERO database (CRD42022310581). DESIGN: Two independent and blinded reviewers carried out a comprehensive search in five databases: PubMed, Cochrane, Scopus, Embase, and Web of Science. Eligible studies were randomized and nonrandomized clinical trials that evaluated in vivo microbiological load or clinical outcomes after using supplementary PDT in infected primary teeth. RESULTS: After the selection process, four studies met the inclusion criteria and were included in this study. Data regarding the sample characteristics and PDT protocols were retrieved. All included trials used phenothiazinium salts as photosensitizer agents. Only one study observed a significant difference in the in vivo microbiological load reduction outcome when performing PDT on primary teeth. The remaining studies all discussed the possible benefits of this intervention; however, none observed a significant difference in this outcome. CONCLUSION: In this systematic review, moderate-to-low certainty of the available evidence was observed, and thus, no significant conclusions can be drawn from the findings.

Prosthetic rehabilitation with removable dentures positively influences quality of life in older patients: a systematic review / A reabilitação protética com próteses removíveis influencia positivamente a qualidade de vida de pacientes idosos: uma revisão sistemática

OBJECTIVE: This systematic review assessed the effects of prosthetic rehabilitation with removable dentures on oral health-related quality of life (OHRQoL) in older adults. METHODS: A comprehensive electronic search was conducted in the PubMed/MEDLINE, Web of Science, and Cochrane databases to identify randomized clinical trials and prospective clinical studies. The included studies evaluated the effects of prosthetic rehabilitation on OHRQoL in patients whose mean age was > 60 years. The interventions included complete dentures, implant-retained overdentures, and removable partial prostheses, with a minimum follow-up period of 1 month after prosthetic rehabilitation. Patient-reported outcome measures, specifically OHRQoL, were the primary outcome. Risk of bias was assessed using the Cochrane RoB 2 tool for randomized clinical trials and the ROBINS-I tool for prospective clinical studies. RESULTS: Eleven articles were considered eligible for the systematic review. The findings indicated that removable dentures improved various OHRQoL domains, mainly functional limitations and physical and psychological disabilities. Retention, stability, comfort, speech, and masticatory efficiency were significantly better with implant overdentures than complete dentures, leading to higher patient satisfaction and OHRQoL. CONCLUSIONS: This systematic review suggests that prosthetic rehabilitation with removable dentures has a positive influence on OHRQoL in older patients. The findings highlight the beneficial impact of implant overdentures and fixed adhesive prostheses for enhancing functional outcomes and patient satisfaction.

OBJETIVO: Esta revisão sistemática avaliou os efeitos da reabilitação protética com próteses removíveis na qualidade de vida relacionada à saúde bucal (QVRSB) em pacientes idosos. METODOLOGIA: Foi realizada uma pesquisa eletrônica abrangente nas bases de dados United States National Library of Medicine/ Medical Literature Analysis and Retrieval System Online ­ PubMed/MEDLINE, Web of Science e Cochrane para identificar ensaios clínicos randomizados (ECR) e estudos clínicos prospectivos. Os artigos selecionados tiveram como foco avaliar o efeito da reabilitação protética na QVRSB em indivíduos com média de idade superior a 60 anos. As intervenções descritas incluíram próteses totais, overdentures suportadas por implantes e próteses parciais removíveis, com acompanhamento mínimo de um mês após a reabilitação protética. As medidas de resultados relatadas pelos pacientes, especificamente QVRSB, foram o desfecho primário. O risco de viés foi avaliado com a ferramenta Cochrane RoB 2 pare ensaios clínicos randomizados e a ferramenta ROBINS-I para estudos clínicos prospectivos. RESULTADOS: Os resultados mostraram que as próteses dentárias removíveis melhoraram vários domínios da QVRSB, principalmente limitações funcionais e físicas e deficiências psicológicas. A retenção, estabilidade, conforto, fala e eficiência mastigatória foram significativamente melhores com overdentures sobre implantes do que com próteses totais, levando a maior satisfação do paciente e QVRSB. CONCLUSÕES: Esta revisão sistemática sugere uma influência positiva da reabilitação protética com próteses removíveis na QVRSB em pacientes idosos. As descobertas destacam o impacto benéfico das overdentures sobre implantes e das próteses adesivas fixas para melhorar os resultados funcionais e a satisfação do paciente

Effect of alpha-humulene incorporation on the properties of experimental light-cured periodontal dressings.

The objective of this study was to formulate an experimental light-cured periodontal dressing containing alpha-humulene and to compare its physical, antimicrobial, and cytotoxicity properties with commercial gold standards (Barricaid® and Periobond®). Two periodontal dressing formulations were developed (a and b). The formulations were divided into 5 groups according to the alpha-humulene concentration as follows: Ea - control group, Ea1 - 1%, Ea5 - 5%, Ea10 - 10%, and Ea20 - 20%; Eb - control group, Eb1 - 1%, Eb5 - 5%, Eb10 - 10%, and Eb20 - 20%. Materials characterization was performed using the degree of conversion, cohesive strength, sorption, and solubility assays. Antimicrobial assay was performed using the modified direct contact test against E. faecalis and S. aureus. Cytotoxicity was assessed by the cell viability experiment using L929 fibroblasts. In general, the cohesive strength values of materials decreased as the alpha-humulene concentration increased. All the experimental dressings showed antimicrobial activity against both bacteria tested. Cell viability results for the Ea, Ea1, Eb, and Eb1 groups showed moderate cytotoxic effect. The formulations containing alpha-humulene showed similar behavior to the commercial references. Thus, formulations containing alpha-humulene have potential to be used as periodontal dressing.

Effect of alpha-humulene incorporation on the properties of experimental light-cured periodontal dressings

Abstract The objective of this study was to formulate an experimental light-cured periodontal dressing containing alpha-humulene and to compare its physical, antimicrobial, and cytotoxicity properties with commercial gold standards (Barricaid® and Periobond®). Two periodontal dressing formulations were developed (a and b). The formulations were divided into 5 groups according to the alpha-humulene concentration as follows: Ea - control group, Ea1 - 1%, Ea5 - 5%, Ea10 - 10%, and Ea20 - 20%; Eb - control group, Eb1 - 1%, Eb5 - 5%, Eb10 - 10%, and Eb20 - 20%. Materials characterization was performed using the degree of conversion, cohesive strength, sorption, and solubility assays. Antimicrobial assay was performed using the modified direct contact test against E. faecalis and S. aureus. Cytotoxicity was assessed by the cell viability experiment using L929 fibroblasts. In general, the cohesive strength values of materials decreased as the alpha-humulene concentration increased. All the experimental dressings showed antimicrobial activity against both bacteria tested. Cell viability results for the Ea, Ea1, Eb, and Eb1 groups showed moderate cytotoxic effect. The formulations containing alpha-humulene showed similar behavior to the commercial references. Thus, formulations containing alpha-humulene have potential to be used as periodontal dressing.

Intentional foraminal enlargement: a systematic review with bibliometric analysis / Ampliação foraminal intencional: uma revisão sistemática com análise bibliométrica

Objective: The purpose of this systematic review with bibliometric analysis was to map the available scientific evidence on intentional foraminal enlargement (IFE) and explore publication trends. Methods: This review is in accordance with the PRISMA 2020 Statement and is registered on the Open Science Framework. Two independent reviewers carried out a comprehensive search of seven databases (PubMed/MEDLINE, Cochrane Library, Scopus, Embase, Web of Science, LILACS, and BBO) up to January 31 st, 2022. Studies that investigated IFE were considered eligible, and the data were analyzed using the VOSViewer software. Results:The search identified a total of 55 IFE-related articles from 10 countries and 25 journals, with an increasing trend for publications over the last decade. The majority of evidence was based on laboratory assays (65.4%), followed by randomized clinical trials (18.1%) with follow-up periods of up to 2 months. The main clinical outcome evaluated was post-operative pain. The highest number of studies were carried out by the State University of Campinas, and published in the Journal of Endodontics. Also, studies with the highest level of evidence found that IFE resulted in greater post-operative pain in the initial days post-treatment. Conclusion:This systematic review with bibliometric analysis mapped the scientific progress and publication trends in the field of IFE, thus shedding light on gaps in the literature with the aim of guiding researchers to conduct more high-impact investigations by performing clinical studies evaluating rates of periapical repair and IFE treatment success using long-term observation periods (AU)

Objetivo: O objetivo desta revisão sistemática com análise bibliométrica foi mapear as evidências científicas disponíveis sobre ampliação foraminal intencional (IFE) e explorar as tendências de publicação. Métodos: Esta revisão está de acordo com a declaração PRISMA 2020 e está registrada no Open Science Framework. Dois revisores independentes realizaram uma busca abrangente em sete bases de dados (PubMed/MEDLINE, Cochrane Library, Scopus, Embase, Web of Science, LILACS e BBO) até 31 de janeiro de 2022. Os estudos que investigaram IFE foram considerados elegíveis e os dados foram analisados usando o software VOSViewer. Resultados: A busca identificou um total de 55 artigos relacionados ao IFE provenientes de 10 países e 25 periódicos, com tendência crescente de publicações na última década. A maioria das evidências foi baseada em ensaios laboratoriais (65,4%), seguido de ensaios clínicos randomizados (18,1%) com períodos de follow-up de até 2 meses. O principal desfecho clínico avaliado foi a dor pós-operatória. O maior número de estudos foi realizado pela Universidade Estadual de Campinas e publicado no Journal of Endodontics. Estudos com os maiores níveis de evidência constataram que IFE resultou em maior dor pós-operatória nos primeiros dias pós- tratamento. Conclusão: Esta revisão sistemática com análise bibliométrica mapeou o progresso científico e as tendências de publicação na área de IFE, lançando luz sobre lacunas na literatura com o objetivo de orientar pesquisadores a realizar investigações de maior impacto, realizando estudos clínicos avaliando taxas de reparo periapical e sucesso do tratamento usando essa técnica e com acompanhamento à longo prazo. (AU)

Evaluation of physical and biological properties of conventional glass ionomer cements / Avaliação das propriedades físicas e biológicas de cimentos de ionômero de vidro convencionais

Objetivo: avaliar as propriedades físicas e biológicas dos cimentos de ionômero de vidro convencionais (CIVs). Metodologia: foram avaliados os seguintes CIVs: Fuji IX (GC Europe, Bélgica), Ketac Molar (3M ESPE, Estados Unidos), Maxxion R (FGM, Brasil) e Vitro Molar (Nova DFL, Brasil). O tempo de presa, a alteração dimensional, a radiopacidade, a sorção e a solubilidade em água foram avaliados para todos os materiais. A resistência à compressão foi analisada em intervalos de 1h, 24h, 7 dias e 28 dias; e liberação de íons fluoreto em 3h, 24h e 72h. A viabilidade celular foi avaliada após 24 e 48 horas com células de fibroblastos. A análise estatística foi realizada por meio do software SigmaPlot 12 (Systat Inc, San Jose, CA, EUA), com nível de significância estabelecido em α = 0,05. Resultado: apenas o Fuji IX teve um tempo de presa dentro da faixa recomendada pela Especificação Padrão da ADA 96 (2012), não superior a 6 minutos. Vitro Molar e Maxxion R apresentaram radiopacidade que não estava de acordo com a especificação ADA 96 (2012). Maxxion R e Vitro Molar mostraram uma alteração dimensional estatisticamente semelhante. Quanto às propriedades mecânicas, o Fuji IX foi o único CIV que apresentou aumento da resistência à compressão durante o período de avaliação de 28 dias. O Ketac Molar apresentou a maior viabilidade celular, enquanto o Maxxion R apresentou citotoxicidade severa e o maior valor cumulativo de liberação de flúor. Conclusão: Fuji IX e Ketac Molar apresentaram as propriedades físicas e biológicas mais adequadas entre os CIVs avaliados.(AU)

Objective: to evaluate the physical and biological properties of conventional glass ionomer cements (GICs). Methodology: the following GICs were evaluated: Fuji IX (GC Europe, Belgium), Ketac Molar (3M ESPE, United States), Maxxion R (FGM, Brazil) and Vitro Molar (Nova DFL, Brazil). Setting time, dimensional change, radiopacity, water solubility and water absorption were evaluated for all materials. Compressive strength was analyzed after intervals of 1h, 24h, 7 days and 28 days; and release of fluoride ions at 3 am, 24 am and 72 am. Cell viability was assessed after 24 and 48 hours with fibroblast cells. Statistical analysis was performed using SigmaPlot 12 software (Systat Inc, San Jose, CA, USA), with a significance level set at α = 0.05. Result: only the Fuji IX had an adjustment time within the range recommended by the Standard Specification of ADA 96 (2012) of not exceeding 6 minutes. Vitro Molar and Maxxion R had radiopacity that was not in accordance with the ADA 96 (2012) specification. Maxxion R and Vitro Molar showed a statistically similar dimensional change. As for mechanical properties, Fuji IX was the only GIC that showed an increase in compressive strength during the evaluation period of 28 days. Ketac Molar showed the highest cell viability, while Maxxion R showed severe cytotoxicity and the highest cumulative fluoride release value. Conclusion: Fuji IX and Ketac Molar showed the most appropriate physical and biological properties among the evaluated GICs.(AU)

Evaluation of dentin hypersensitivity treatment with glass ionomer cements: A randomized clinical trial.

A randomized, double-blind, split-mouth clinical trial was performed compared the desensitizing efficacy of the resin-modified glass ionomer cement (GIC) ClinproTM XT (3M ESPE, Minnesota, USA) and the conventional GIC Vidrion R (SS White, Gloucester, UK) in a 6-month follow-up. Subjects were required to have at least two teeth with dentin hypersensitivity. Teeth were divided at random into 2 groups, one group received Clinpro XT and the other conventional GIC Vidrion R. Treatments were assessed by tactile and air blast tests using Visual Analogue Scale (VAS) at baseline, after 20 minutes, and at 7, 15, 21, 30, 90 and 180 days post-treatment. Twenty subjects (152 teeth) were included. Both tests (tactile and air blast) showed a significant reduction of dentin hypersensitivity immediately after the application of Vidrion R and Clinpro XT (20 min). VAS scores obtained along the 6-month follow-up were statistically lower when compared to initial rates (p < 0.05). Both GIC were able to reduce dentin hypersensitivity up to 6-month post-treatment period without statistically significant differences among them (p > 0.05). Both cements provided satisfactory results in long-term dental sensitivity reduction.

Evaluation of dentin hypersensitivity treatment with glass ionomer cements: A randomized clinical trial

Abstract A randomized, double-blind, split-mouth clinical trial was performed compared the desensitizing efficacy of the resin-modified glass ionomer cement (GIC) ClinproTM XT (3M ESPE, Minnesota, USA) and the conventional GIC Vidrion R (SS White, Gloucester, UK) in a 6-month follow-up. Subjects were required to have at least two teeth with dentin hypersensitivity. Teeth were divided at random into 2 groups, one group received Clinpro XT and the other conventional GIC Vidrion R. Treatments were assessed by tactile and air blast tests using Visual Analogue Scale (VAS) at baseline, after 20 minutes, and at 7, 15, 21, 30, 90 and 180 days post-treatment. Twenty subjects (152 teeth) were included. Both tests (tactile and air blast) showed a significant reduction of dentin hypersensitivity immediately after the application of Vidrion R and Clinpro XT (20 min). VAS scores obtained along the 6-month follow-up were statistically lower when compared to initial rates (p < 0.05). Both GIC were able to reduce dentin hypersensitivity up to 6-month post-treatment period without statistically significant differences among them (p > 0.05). Both cements provided satisfactory results in long-term dental sensitivity reduction.

Endocrown restorations: A systematic review and meta-analysis.

OBJECTIVES: A systematic review was conducted to evaluate clinical (survival) and in vitro (fracture strength) studies of endocrown restorations compared to conventional treatments (intraradicular posts, direct composite resin, inlay/onlay). DATA: This report followed the PRISMA Statement. A total of 8 studies were included in this review. SOURCES: Two reviewers performed a literature search up to February 2016 in seven databases: PubMed, Web of Science, Scopus, BBO, SciELO, LILACS and IBECS. STUDY SELECTION: Only clinical trials and in vitro studies that evaluated endocrowns were included. Case reports, case series, pilot studies, reviews and in vitro studies that evaluated properties other than fracture strength of endocrowns were excluded. From the 103 eligible articles, 8 remained in the qualitative analysis (3 clinical trials and 5 in vitro studies), and the meta-analysis was performed for the 5 in vitro studies. A global comparison was performed with random-effects models at a significance level of p<0.05. RESULTS: Clinical trials showed a success rate of endocrowns varying from 94 to 100%. The global analysis in posterior and anterior teeth demonstrated that endocrowns had higher fracture strength than conventional treatments (p=0.03). However, when comparing endocrowns to conventional treatments only in posterior teeth (subgroup analyses), no statistically significant differences were found between treatments (p=0.07; I(2)=62%). CONCLUSION: The literature suggests that endocrowns may perform similarly or better than the conventional treatments using intraradicular posts, direct composite resin or inlay/onlay restorations. CLINICAL SIGNIFICANCE: Although further studies are still necessary to confirm the present findings, endocrowns show potential application for the rehabilitation of severely compromised, endodontically treated teeth.

A systematic review about antibacterial monomers used in dental adhesive systems: Current status and further prospects.

OBJECTIVES: This study systematically review the literature to assess the effectiveness of antibacterial monomers incorporated into dental adhesive systems against major oral bacteria; as well as the research advances and the future prospects of this technology. METHODS: The following seven databases were screened: MedLine (PubMed), Lilacs, Ibecs, Web of Science, Scopus, Scielo, and The Cochrane Library. Furthermore, the online system Questel Orbit (Paris, France) was accessed to obtain patent data. The inclusion criteria were articles and patents that investigated the antimicrobial activity of antibacterial monomers in dental adhesive systems. Only documents written in English, Spanish or Portuguese were included. RESULTS: After screening, 33 studies and eight patents fulfilled all the criteria and were included. Antibacterial agents, such as QA, MDPB, DMAHM and DMADDM were found in patents, which claimed their incorporation into adhesive compositions, dental cements, composite resins. MDPB was the only antimicrobial monomer incorporated into a commercially available adhesive system, Clearfil Protect Bond™ (Kuraray Co. Ltd., Japan). All studies reported the inclusion of antimicrobial monomers in adhesive systems to be an effective dental treatment strategy. SIGNIFICANCE: There are potential areas to be explored with antibacterial monomers for dentistry, and their use could have important implications for future more conservative dental treatments. Although there is evidence of antibacterial activity from in vitro studies, clinical studies must be conducted to confirm the effectiveness of these materials in the prevention of dental pathologies.

Bond strength of universal adhesives: A systematic review and meta-analysis.

OBJECTIVES: A systematic review was conducted to determine whether the etch-and-rinse or self-etching mode is the best protocol for dentin and enamel adhesion by universal adhesives. DATA: This report followed the PRISMA Statement. A total of 10 articles were included in the meta-analysis. SOURCES: Two reviewers performed a literature search up to October 2014 in eight databases: PubMed, Web of Science, Scopus, BBO, SciELO, LILACS, IBECS and The Cochrane Library. STUDY SELECTION: In vitro studies evaluating the bond strength of universal adhesives to dentin and/or enamel by the etch-and-rinse and self-etch strategies were eligible to be selected. Statistical analyses were conducted using RevMan 5.1 (The Cochrane Collaboration, Copenhagen, Denmark). A global comparison was performed with random-effects models at a significance level of p<0.05. RESULTS: The analysis of dentin micro-tensile bond strength showed no statistically significant difference between the etch-and-rinse and self-etch strategies for mild universal adhesives (p≥0.05). However, for the ultra-mild All-Bond Universal adhesive, the etch-and-rinse strategy was significantly different than the self-etch mode in terms of dentin micro-tensile bond strength, as well as in the global analysis of enamel micro-tensile and micro-shear bond strength (p≤0.05). CONCLUSIONS: The enamel bond strength of universal adhesives is improved with prior phosphoric acid etching. However, this effect was not evident for dentin with the use of mild universal adhesives with the etch-and-rinse strategy. CLINICAL SIGNIFICANCE: Selective enamel etching prior to the application of a mild universal adhesive is an advisable strategy for optimizing bonding.